Recombinant ZEB1 antibody (C-Term)

Catalog No. ABIN7795625

This Rabbit Monoclonal antibody specifically detects ZEB1 in WB, FACS and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for Recombinant ZEB1 antibody (C-Term) (ABIN7795625)

Target: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ZEB1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: BLR102H

Product Details anti-ZEB1 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-ZEB1 Recombinant Monoclonal Antibody [BLR102H] - BSA-Free

Purification: Purified

Immunogen: Between 1074 and C-terminus

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.09 % Sodium Azide, BSA-Free

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for ZEB1

Target: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Alternative Name: ZEB1

Background: ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.

Gene ID: 6935

UniProt: P37275

Pathways: Regulation of Muscle Cell Differentiation